Patents&Papers

 

Patents

 
 

Lewis, I.A. and Rydzak, T. Metabolomic characterization of microorganisms

  • CA3139767 (issued)

  • US17/615,256 (pending)

  • CA3236928 (pending)

  • AU2019448735 (pending)

  • EP19930630.9 (pending)

  • CN201980098971.5 (issued)

Lewis, I.A. Device, method, and system for identifying organisms and determining their sensitivity to toxic substances using the changes in the concentrations of metabolites present in growth medium

  • AU2018235992B2 (issued)

  • US2020010870A1 (pending)

  • CA3056149A1 (pending)

  • EP3596227A4 (pending)

Lewis, I.A., Gregson, D., and Groves, R. Method for detecting urinary tract infections and sample analysis using liquid chromatography

  • CA3102113C (issued)

  • EP3803390B1 (issued)

  • GB3803390 (issued)

  • US20210215668A1 (pending)

  • AU2019275957B2 (issued)

  • CN112513632A (pending)

 

Selected Papers

 

Chan, C.C.Y., Groves, R.A, Aburashed R., Rydzak, T., Lewis, I.A. LC-MS system for automatically collecting time-resolved metabolomics data of cultured cells. Analytical Chemistry 2025 97 (19), 10145-10148. doi: 10.1021/acs.analchem.4c06697

Chan, C.C.Y., Gregson, D.B., Wildman, S.D., Bihan, D.G., Groves R.A., Aburashed, R., Rydzak T, Pittman, K, Van Bavel, N., Lewis, I.A. Metabolomics strategy for diagnosing urinary tract infections. Nat Commun 16, 2658. 2025. doi: 10.1038/s41467-025-57765-y

Lewis IA. Boundary Flux Analysis (BFA): an emerging strategy for investigating metabolic pathway activity in large cohorts. Current Opinions in Biotechnology. 2023. 85:10327. doi: 10.1016/j.copbio.2023.103027

Groves, R.A., Chan, C.C.Y., Wildman, S.D., Gregson, D.B., Rydzak T., Lewis, I.A. Rapid LC–MS assay for targeted metabolite quantification by serial injection into isocratic gradients. Anal Bioanal Chem 415, 269–276. 2023. doi: 10.1007/s00216-022-04384-x 

Mapar M, Rydzak T, Groves RA, Lewis IA. Biomarker enrichment medium: A defined medium for metabolomic analysis of microbial pathogens. Front Microbiol. 2022. doi: 10.3389/fmicb.2022.957158

Rydzak T, Groves RA, Zhang R et al. Metabolic preference assay for rapid diagnosis of bloodstream infections. Nat Commun. 2022. doi: 10.1038/s41467-022-30048-6

Groves RA, Mapar M, Aburashed R, Ponce LF, Bishop SL, Rydzak T, Drikic M, Bihan DG, Benediktsson H, Clement F, Gregson DB, Lewis IA. Methods for Quantifying the Metabolic Boundary Fluxes of Cell Cultures in Large Cohorts by High-Resolution Hydrophilic Liquid Chromatography Mass Spectrometry. Anal Chem. 2022. doi: 10.1021/acs.analchem.2c00078.

Mohammadi M, Bishop SL, Aburashed R, Luqman S, Groves RA, Bihan DG, Rydzak T, Lewis IA. Microbial Containment Device (MCD): a platform for comprehensive analysis of microbial metabolism without sample preparation. Frontiers in Microbiology. 2022. doi: 10.3389/fmicb.2022.958785