Patents & Papers
Patents
| Patent family | Granted / allowed | Pending |
|---|---|---|
| Family 1 – UTI detection. Method for detecting urinary tract infections and sample analysis using liquid chromatography | US 12,724,025; CA 3,102,113; EP 3 803 390 (Unitary Patent and GB); AU 2019275957 | — |
| Family 2 – Organism ID and AST. Device, method, and system for identifying organisms and determining their sensitivity to toxic substances using the changes in the concentrations of metabolites present in growth medium | AU 2018235992 | US 16/493,565 (RCE filed October 2026); CA 3,056,149; EP divisional 25165353.1 |
| Family 3 – Metabolomic characterization. Metabolomic characterization of microorganisms | US 12,503,719; CA 3,139,767; EP 3976811 (Unitary Patent and GB); CN ZL 2019 8 0098971.5; AU 2019448735 (allowed) | US continuation 19/423,649; CA divisional 3,236,928; AU divisional 2026203627; EP divisional 26153995.1; CN divisional 202510365248.6 |
| Family 4 – Organism AST. Metabolism-based analysis for toxin susceptibility testing and methods | — | PCT/CA2026/050854 (from US provisional 63/827,102) |
Selected Papers
Chan, C.C.Y., Groves, R.A, Aburashed R., Rydzak, T., Lewis, I.A. LC-MS system for automatically collecting time-resolved metabolomics data of cultured cells. Analytical Chemistry 2025 97 (19), 10145-10148. doi: 10.1021/acs.analchem.4c06697
Chan, C.C.Y., Gregson, D.B., Wildman, S.D., Bihan, D.G., Groves R.A., Aburashed, R., Rydzak T, Pittman, K, Van Bavel, N., Lewis, I.A. Metabolomics strategy for diagnosing urinary tract infections. Nat Commun 16, 2658. 2025. doi: 10.1038/s41467-025-57765-y
Lewis IA. Boundary Flux Analysis (BFA): an emerging strategy for investigating metabolic pathway activity in large cohorts. Current Opinion in Biotechnology. 2023. 85:103027. doi: 10.1016/j.copbio.2023.103027
Groves, R.A., Chan, C.C.Y., Wildman, S.D., Gregson, D.B., Rydzak T., Lewis, I.A. Rapid LC–MS assay for targeted metabolite quantification by serial injection into isocratic gradients. Anal Bioanal Chem 415, 269–276. 2023. doi: 10.1007/s00216-022-04384-x
Mapar M, Rydzak T, Groves RA, Lewis IA. Biomarker enrichment medium: A defined medium for metabolomic analysis of microbial pathogens. Front Microbiol. 2022. doi: 10.3389/fmicb.2022.957158
Rydzak T, Groves RA, Zhang R et al. Metabolic preference assay for rapid diagnosis of bloodstream infections. Nat Commun. 2022. doi: 10.1038/s41467-022-30048-6
Groves RA, Mapar M, Aburashed R, Ponce LF, Bishop SL, Rydzak T, Drikic M, Bihan DG, Benediktsson H, Clement F, Gregson DB, Lewis IA. Methods for Quantifying the Metabolic Boundary Fluxes of Cell Cultures in Large Cohorts by High-Resolution Hydrophilic Liquid Chromatography Mass Spectrometry. Anal Chem. 2022. doi: 10.1021/acs.analchem.2c00078.
Mohammadi M, Bishop SL, Aburashed R, Luqman S, Groves RA, Bihan DG, Rydzak T, Lewis IA. Microbial Containment Device (MCD): a platform for comprehensive analysis of microbial metabolism without sample preparation. Frontiers in Microbiology. 2022. doi: 10.3389/fmicb.2022.958785
